MASOUMENT


   



Masoument (a production of Ebnemasouyeh pharmaceutical company) with composition of peppermint and licorice treat for dry and productive coughs.

Herbs specification:
1.mentha piperita:  common name :peppermint ,  family:labiatae

2.Glycyrrhiza glabra: common name: licorice family:papalionaceae

Active constituents:
Peppermint:menthol,menthone,…
Licorice:glycyrrhizin,glycyrrhitic acid

The coughs reflex:
Coughing is a complex protective reflex which is the normal means of cleansing the bronchi, the airway tubes to the lungs,of excessive fluids or unwanted matter. It is associated with other protective process such as mucus secretion.
Causes of coughing include inhaled irritants,inflammations,infections,fibrosis, blood clots tumors or lung congestion from heart insufficiency.
The coughs are 2 types: dry and productive,the coughs of viral infections are at first dry and spasmodic.this type of coughs can either be relived whit coughs suppressants or made productive by expectorant.
Chronic dry coughs are noninfective ,usually due to either fibrosis or congestive heart failure .

Drug mechanism:In treating productive coughs demulcents and antiseptics should be used to soothe the irritation in the throat from coughing and reduce sputum production.
Peppermint oil ad its component, menthol, act as local anesthetic to relieve irritation and as well as being mildly antiseptic.
Inhalation of menthol has been shown to inhibit respiration via stimulation of upper airway cold receptors. so menthol act with 4 mechanism:
1.antiseptic action
2.local anesthetic
3.to influence the activity of cold receptors in the larynx .
4.to influence the upper-airway sensory receptors.
Licorice root acts as a demulcent but its derivatives have been shown to have central antitussive effect similar to codeine.
Licorice is also considered to be a sedative expectorant.in addition its constituents have shown antiviral and immune -stimulating effects.(1,2,3,4,A)

Indications:
1. Dry and productive coughs 1
2. common cold symptoms relief.
3. bad breath treatment
4. to relieve throat irritation

Precaution:
1.people with gallstones and esophageal reflux(5).
2.severe heart and renal failure

Gastroesophageal reflux disease (GERD) is a condition where stomach acids back up into the esophagus. Peppermint can relax the sphincter between the stomach and esophagus, allowing stomach acids to flow back into the esophagus. (The sphincter is the muscle that separates the esophagus from the stomach). By relaxing the sphincter, peppermint may actually make the symptoms of heartburn and indigestion worse.

If one has issues with the gallbladder problems, such as blockage, inflammation or gallstones, peppermint should not be taken. If there are liver problems, peppermint should be avoided until a medical professional says it's okay.

Caution should also be taken in diabetes, pregnancy or breast feeding. 

3. it is not recommended under 8 years old children.

Drug interaction:
people with esophageal reflux should avoid use of menthol-containing herbs,such as peppermint.(6)

Side effect:
Licorice prolonged use can cause mineralocorticodes effect.

Formulation:
500 mg tablet with menthol and licorice extract

Dosage:
2 tablets every 4 hours

Packaging:
50mg Tablets boxes of 100’s and 20’s 500