MENTHAZIN®


Today poly herbal formulation is applied to increase drug efficacy.Ebnemasouyeh menthazin tablet with composition of menthol, licorice extract and fennel oil has indication for gastro-intestinal dysfunction.

Herbal specification:
1-mentha piperita:
common name:peppermint family:labietae

2-glycyrrhiza glabra:
common name : licorice family:papalionaceae

3-foeniculum vulgare:
common name: fennel family:umbeliferea

Active constituents:
Licorice:
• Saponin triterpenes,including glycyrrhizin,glycyrrhetinic acid
• Flavonoids and isoflavonoids, including liquiritin
• Other:coumarins,…
Peppermint:
• menthol, menthone
Fennel:
• anethole


Drug mechanism:
Licorice can protect gastro-intestinal system with increasing production of mucin.

Fennel oil and menthol, are used to stimulate the digestive system to work property.they are very effective to expel gas and easing griping pains from the stomach and the intestines,they also tone the mucouse surfaces and increase peristaltic action.
All licorice derivatives prevent Acetaminophen- induced hepatotoxicity,as reflected by decrease level of serum transaminases and lesser degree of hepatic necrosis.so licorice derivatives must be taken into account as protective agent in hepatotoxicity when large doses of Acetaminophen must be used for period of time.

Indication:
1-carminative
2-colic
3-pepetic ulcer treatment
4-to decrease Acetaminophen side effect in high dose.
Drug interaction:
• licorice and corticosteroids:
Herb affects drug performance by prolonging steroid biological half –life.

Studies have shown that glycyrrhizin  stimulates the excretion of hormones by the adrenal cortex. Some researchers have suggested it can prolong the action of cortisone. Glycyrrhizin has a similar chemical structure to corticosteroids released by the adrenals; therefore it could interfere with their receptors.


• Licorice and loop diuretic:
Potassium –depleting diuretics may potentiate the effects of licoric and thereby increase its toxic effect.
• Licorice and drug toxicity:
Licorice root potentiate the cumulative toxicity of cardiac glycosides including digoxin due to hypokalemic effects.

Contraindication:

• Overweight, hypertensive, cardiac patient
• Severs renal insufficiency
• Hypokalemia
• Pregnancy

Side effect:
Licorice can cause side effect in long- term intake and high dose such as:
• Water- retention
• Blood presure
• hypokalemia
• mineralocorticoid effect

formulation:
500 mg tablet with menthol and fennel oil and licorice extract

Dosage:
2 tablets every 4 hours

packaging:
500 mg tablets boxes of 100?s and 20?s



References:

1) Snow J. Protoc. J. Bot. Med., 1996, 1.3:9-14
2) Goso Y, Ogata Y, Ishihara K, Hottak. Effect of traditional herbal medicine on gastric mucin against ethan injury in rats comp Biochem physiol 1996; 1132:17- 21
3) Beil W, Birkholz W, sewing KF, Effect of flavonoids on partial cell acid secretion, gastric mucosal prosta Helicobacter pylori growth. Arzneimittel for schung 1995 ; 45: 697- 700
4) Dehpour A.R., Zahedi H., Amini sh., Akhgari M., Abdollahi M., Im J med sci, 1999: 24 (182): 26- 31
5) Shiratori K; watanabe S; Takeuchi T.Effect of licorice extract (Fm100) on release of secretin and exocrine pancreatic secretion in humans. Pancreas 1989;1(6):483-7
6) Farse RV, et al. N Engl J Med 1991 oct 24; 325(17): 1223-7
7) Bennett A, et al. J pharm pharmacol 1980 ; 32: 151
8) Miller LG. Arch intern Med 1998 Nov 90, 158(20): 2200- 11

web References:
1. drug store.com
2. nutritionfocus.Com
3. home.caregroup.org
4. sums.ac.ir



Mechanism of action of antipeptic ulcer of licorice in Menthzin tablets:

The stomach is lined with mucosal cells that secrete a protective layer of mucin. This natural protection is effective in guarding the stomach wall against acid damage. If there is an imbalance between acid secretion and mucosal protection, acids can begin to irritate the stomach wall. The presence of harmful intestinal bacteria, such as Helicobacter pylori, can also disrupt this balance. Maintaining normal acidity and supporting the stomach’s natural protective mechanisms are therefore essential for normal stomach function and comfort.

Licorice, or Glycyrrhiza glabra, is a perennial herb, the root of which has been used for over 3,000 years to treat a wide range of complaints, making it one of the most widely used medicinal herbs in history. The root of the licorice plant contains 10 triterpenes and 22 flavonoids, which are the constituents believed to be responsible for its beneficial properties. Flavonoids, in general, are known to inhibit both acid secretion and the growth of harmful intestinal bacteria. According to laboratory research, flavonoids in licorice inhibit growth of H. pylori. The flavonoid component, isoliquiritigen, found in licorice has been shown to protect gastric mucosal cells. Licorice also protects the stomach and duodenum by increasing production of mucin, a substance that protects the lining of these organs against stomach acid and other harmful substances.

In another researches it was revealed that anti-ulcer effects of licorice are due to inhibition of 15-hydroxyprostaglandin dehydrogenase and Δ13-prostaglandin reductase. 15-Hydroxyprostaglandin dehydrogenase converts prostaglandins E2 and F2α to 15-ketoprostaglandins, which are inactive. Δ13-Prostaglandin reductase metabolizes the inactive Δ13-prostaglandin to 13, 14-dihydro, 15-ketoprostaglandin, which is further metabolized and excreted in urine. Thus, licorice-derived compounds have the effect of raising the local concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach, leading to healing of ulcers. 11β-Hydroxysteroid dehydrogenase, which also is inhibited by licorice-derived compounds, shares a common ancestor with 15-hydroxyprostaglandin dehydrogenase. Glycyrrhetinic Acid has also a strong spasmolytic effect against induced spasms in isolated guinea pig intestine.

glycyrrhizic acid (GL), glycyrrhetinic acid (GA) and a novel lipophilic derivative of glycyrrhetinic acid monoglucuronide (GAMG) and acetylated GAMG (aGAMG) were tested  against 29 Helicobacter pylori strains. The potent in vitro activity of GA against H. pylori provides a further explanation for its beneficial effect on peptic ulcers. Its effectiveness against clarithromycin-resistant strains provides hope that it can form the basis for an alternative therapeutic agent against H. pylori.

Liquorice derivative, carbenoxolone, is synthesized from glycyrrhetinic acid (the aglycone of glycyrrhizinic acid) and is of proven value in the treatment of gastric ulcer.